WHO-GMP & PIC/S Certified
Serving 50+ Countries
Delios Lifesciences
Delios
Lifesciences
Product Category

Oncology Products

Cytotoxic and targeted therapy formulations manufactured in dedicated high-potency API (HPAPI) facilities with specialized containment, validated cleaning procedures, and strict safety protocols for oral and injectable dosage forms

WHO-GMP Certified
PIC/S Approved
Global Standards

HPAPI Containment & Safety Excellence

Dedicated high-potency API manufacturing capabilities for cytotoxic and targeted oncology therapies with rigorous containment and safety controls

HPAPI Oncology Manufacturing
Quality Control
Cytotoxic Packaging Line

HPAPI Containment & Safety Excellence

Our oncology portfolio includes 80+ chemotherapy and targeted therapy formulations manufactured in dedicated HPAPI facilities with occupational exposure limits (OEL) <1 μg/m³. Utilizing containment technology (isolators, RABS), negative pressure manufacturing areas, and validated cleaning procedures, we ensure operator safety and prevent cross-contamination.

All oncology products undergo potency testing, sterility testing (for injectables), particulate matter analysis, and stability studies under refrigerated conditions (2-8°C) where required, meeting the strictest international quality and safety standards.

  • Dedicated HPAPI manufacturing suite with negative pressure
  • Occupational Exposure Limit (OEL) <1 μg/m³
  • Isolator/RABS containment technology for powder handling
  • Validated cleaning procedures (<10 ppm residue limits)
  • Specialized packaging with cytotoxic hazard warnings

HPAPI Containment Process

Specialized high-potency containment process ensuring operator safety, product quality, and regulatory compliance at every stage

01
HPAPI Handling

HPAPI Handling in Containment Isolators

High-potency active pharmaceutical ingredients are weighed and dispensed inside validated isolators to prevent operator exposure and cross-contamination.

  • Isolator/RABS containment for all powder handling
  • Occupational Exposure Limit (OEL) <1 μg/m³ maintained
  • Real-time airborne particulate monitoring
  • Certificate of Analysis (COA) review before dispensing
02
Negative Pressure Manufacturing

Manufacturing in Dedicated Oncology Suite (Negative Pressure)

Formulation and blending take place in a dedicated oncology-only manufacturing suite maintained under negative pressure to contain hazardous particulates.

  • Dedicated negative-pressure manufacturing rooms
  • Segregated air handling with HEPA filtration
  • Personal protective equipment (double gloving, respirators)
  • In-process potency and uniformity checks
03
Aseptic Cytotoxic Processing

Aseptic Processing for Injectable Cytotoxics

Injectable oncology formulations are aseptically filled under Grade A laminar airflow within isolators to maintain sterility and full containment.

  • Grade A (ISO 5) aseptic filling within closed isolators
  • Sterility testing per USP <71>
  • Automated fill-volume and weight monitoring
  • 100% visual inspection for particulates
04
Validated Cleaning

Validated Cleaning Procedures (<10 ppm residue)

Equipment and facility cleaning is validated to residue limits below 10 ppm, preventing cross-contamination between oncology and other product lines.

  • Validated cleaning protocols per batch changeover
  • Swab and rinse sampling for residue verification
  • Dedicated cleaning equipment for HPAPI areas
  • Documented cleaning verification records
05
Cytotoxic Packaging

Specialized Packaging with Cytotoxic Warnings

Finished products are packaged with prominent cytotoxic hazard labeling, secondary containment, and personnel environmental monitoring before release.

  • Cytotoxic hazard warning labels on all packaging
  • Secondary containment for safe handling and transport
  • Personnel and environmental monitoring during packaging
  • Final QC potency approval and batch release

Technical Capabilities

Specialized HPAPI manufacturing environment and safety controls for oncology formulations

Manufacturing Environment

Dedicated HPAPI suite maintained under negative pressure with segregated air handling

Occupational Exposure Limit

OEL <1 μg/m³ maintained throughout handling and manufacturing

Containment

Isolators and RABS (Restricted Access Barrier Systems) for all powder handling

Sterility (Injectables)

Tested per USP <71> for all injectable oncology formulations

Potency

95-105% of labeled amount, verified through rigorous batch testing

Storage

Many oncology formulations require 2-8°C cold-chain refrigeration

Manufacturing Equipment
Quality Testing
Laboratory
Clean Room

Oncology Product Categories

Comprehensive oncology portfolio across major cancer types and treatment modalities

Antibiotics

Alkylating Agents

Cyclophosphamide, Ifosfamide, Temozolomide

Analgesics

Antimetabolites

5-Fluorouracil, Methotrexate, Gemcitabine

Cardiovascular

Taxanes

Paclitaxel, Docetaxel formulations

Anti-Diabetic

Anthracyclines

Doxorubicin, Daunorubicin, Epirubicin

Gastrointestinal

Platinum Compounds

Cisplatin, Carboplatin, Oxaliplatin

Respiratory

Targeted Therapies

Tyrosine kinase inhibitors, mAbs biosimilars

CNS

Immunotherapy

PD-1/PD-L1 inhibitors, checkpoint modulators

Vitamins

Vitamins & Supplements

Tamoxifen, Letrozole, Bicalutamide

Packaging Solutions

Multiple packaging options designed for product protection and market compliance

Cytotoxic-Warning Vials
Primary

Cytotoxic-Warning Vials

Amber glass vials with prominent cytotoxic hazard labeling and tamper-evident seals for injectable oncology products.

Child-Resistant Bottles
Primary

Child-Resistant Bottles

HDPE bottles with child-resistant closures and cytotoxic warning labels for oral chemotherapy products.

Secondary Containment Packaging
Primary

Secondary Containment Packaging

Additional protective outer packaging ensuring safe handling and transport of hazardous cytotoxic drugs.

Related Products

Discover our complete range of pharmaceutical formulations

WHO-GMP

Certified

PIC/S

Approved

ISO 9001:2015

Certified

GDP

Compliant

FDA

Ready